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Tight Binding of Heme to Staphylococcus aureus IsdG and IsdI Precludes Design of a Competitive Inhibitor

The micromolar equilibrium constants for heme dissociation from IsdG and IsdI reported in the literature call into question whether these enzymes are actually members of the iron-regulated surface determinant system of Staphylococcus aureus, which harvests heme iron from a host during infection. In...

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Detalhes bibliográficos
Publicado no:Metallomics
Main Authors: Conger, Matthew A., Pokhrel, Deepika, Liptak, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510889/
https://ncbi.nlm.nih.gov/pubmed/28401968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7mt00035a
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