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Tight Binding of Heme to Staphylococcus aureus IsdG and IsdI Precludes Design of a Competitive Inhibitor
The micromolar equilibrium constants for heme dissociation from IsdG and IsdI reported in the literature call into question whether these enzymes are actually members of the iron-regulated surface determinant system of Staphylococcus aureus, which harvests heme iron from a host during infection. In...
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| Wydane w: | Metallomics |
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| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5510889/ https://ncbi.nlm.nih.gov/pubmed/28401968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7mt00035a |
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