Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model

BACKGROUND: Despite considerable investigational efforts, no method to overcome the pathogenesis caused by loss of function (LoF) mutations in tumor suppressor genes has been successfully translated to the clinic. The most frequent LoF mutation in human cancers is Adenomatous polyposis coli (APC), c...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Hochman, Gili, Halevi-Tobias, Karin, Kogan, Yuri, Agur, Zvia
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510801/
https://ncbi.nlm.nih.gov/pubmed/28708837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179888
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