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Repetitive Closed-Head Impact Model of Engineered Rotational Acceleration Induces Long-Term Cognitive Impairments with Persistent Astrogliosis and Microgliosis in Mice

Repeated mild traumatic brain injury (rmTBI) has been identified by epidemiology as a high-risk factor for dementia at a later stage in life. Animal models to replicate complex features of human rmTBI and/or to evaluate long-term effects on brain function have not been established. In this study, we...

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Pubblicato in:J Neurotrauma
Autori principali: Chen, Huazhen, Desai, Abhishek, Kim, Hee-Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510798/
https://ncbi.nlm.nih.gov/pubmed/28288551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2016.4870
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