T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

Histone acetylation and the families of enzymes responsible for controlling these epigenetic marks have been implicated in regulating T-cell maturation and phenotype. Here, we demonstrate a previously undefined role of histone deacetylase 11 (HDAC11) in regulating T-cell effector functions. Using EG...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Woods, David M., Woan, Karrune V., Cheng, Fengdong, Sodré, Andressa L., Wang, Dapeng, Wu, Yongxia, Wang, Zi, Chen, Jie, Powers, John, Pinilla-Ibarz, Javier, Yu, Yu, Zhang, Ya, Wu, Xuefeng, Zheng, Xiaoyan, Weber, Jeffrey, Hancock, Wayne W., Seto, Edward, Villagra, Alejandro, Yu, Xue-Zhong, Sotomayor, Eduardo M.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2017
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510785/
https://ncbi.nlm.nih.gov/pubmed/28550044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-731505
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