Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis

Infection of weanling C57BL/6 mice with the TE strain of Sindbis virus (SINV) causes nonfatal encephalomyelitis associated with hippocampal-based memory impairment that is partially prevented by treatment with 6-diazo-5-oxo-l-norleucine (DON), a glutamine antagonist (Potter et al., J Neurovirol 21:1...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Baxter, Victoria K., Glowinski, Rebecca, Braxton, Alicia M., Potter, Michelle C., Slusher, Barbara S., Griffin, Diane E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510753/
https://ncbi.nlm.nih.gov/pubmed/28531865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.05.013
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