MDR1-deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

The multidrug-resistance-1 (MDR1) gene encodes an ATP-dependent efflux transporter that is highly expressed in the colon. In mice, loss of MDR1 function results in colitis with similarities to human inflammatory bowel diseases (IBD). Here, we show that MDR1 has an unexpected protective role for the...

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Gepubliceerd in:Mucosal Immunol
Hoofdauteurs: Ho, Gwo-Tzer, Aird, Rhona E, Liu, Bo, Boyapati, Ray K, Kennedy, Nicholas A, Dorward, David A, Noble, Colin L, Shimizu, Takahiko, Carter, Roderick N, Chew, Etienne TS, Morton, Nicholas M, Rossi, Adriano G, Sartor, R. Balfour, Iredale, John P, Satsangi, Jack
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510721/
https://ncbi.nlm.nih.gov/pubmed/28401939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2017.31
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