Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin producing neurons

Recent advances in three dimensional (3D) culture systems have led to the generation of brain organoids that resemble different human brain regions; however, a 3D organoid model of the midbrain containing functional midbrain dopaminergic (mDA) neurons has not been reported. We developed a method to...

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Gepubliceerd in:Cell Stem Cell
Hoofdauteurs: Jo, Junghyun, Xiao, Yixin, Sun, Alfred Xuyang, Cukuroglu, Engin, Tran, Hoang-Dai, Göke, Jonathan, Tan, Zi Ying, Saw, Tzuen Yih, Tan, Cheng-Peow, Lokman, Hidayat, Lee, Younghwan, Kim, Donghoon, Ko, Han Seok, Kim, Seong-Oh, Park, Jae Hyeon, Cho, Nam-Joon, Hyde, Thomas M, Kleinman, Joel E, Shin, Joo Heon, Weinberger, Daniel R., Tan, Eng King, Je, Hyunsoo Shawn, Ng, Huck Hui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510242/
https://ncbi.nlm.nih.gov/pubmed/27476966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.07.005
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