Safety and Efficacy of Memantine in Children with Autism: Randomized, Placebo-Controlled Study and Open-Label Extension

Objective: Abnormal glutamatergic neurotransmission is implicated in the pathophysiology of autism spectrum disorder (ASD). In this study, the safety, tolerability, and efficacy of the glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist memantine (once-daily extended-release [ER]) were inv...

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Detalhes bibliográficos
Publicado no:J Child Adolesc Psychopharmacol
Main Authors: Aman, Michael G., Findling, Robert L., Hardan, Antonio Y., Hendren, Robert L., Melmed, Raun D., Kehinde-Nelson, Ola, Hsu, Hai-An, Trugman, Joel M., Palmer, Robert H., Graham, Stephen M., Gage, Allyson T., Perhach, James L., Katz, Ephraim
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510039/
https://ncbi.nlm.nih.gov/pubmed/26978327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cap.2015.0146
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