Inhibition of the CRF(1) receptor influences the activity of antidepressant drugs in the forced swim test in rats

Hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA) and impairment of the central corticotropin-releasing factor (CRF) system are factors in the pathogenesis of depression. Though several antagonists of the CRF(1) receptor were effective in the recognized behavioral tests for antidepressa...

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Pubblicato in:Naunyn Schmiedebergs Arch Pharmacol
Autori principali: Wróbel, Andrzej, Serefko, Anna, Szopa, Aleksandra, Rojek, Karol, Poleszak, Ewa, Skalicka-Woźniak, Krystyna, Dudka, Jarosław
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509780/
https://ncbi.nlm.nih.gov/pubmed/28429110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-017-1377-0
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