UL36 Rescues Apoptosis Inhibition and In vivo Replication of a Chimeric MCMV Lacking the M36 Gene

Apoptosis is an important defense mechanism mounted by the immune system to control virus replication. Hence, cytomegaloviruses (CMV) evolved and acquired numerous anti-apoptotic genes. The product of the human CMV (HCMV) UL36 gene, pUL36 (also known as vICA), binds to pro-caspase-8, thus inhibiting...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Infect Microbiol
Hauptverfasser: Chaudhry, M. Zeeshan, Kasmapour, Bahram, Plaza-Sirvent, Carlos, Bajagic, Milica, Casalegno Garduño, Rosaely, Borkner, Lisa, Lenac Roviš, Tihana, Scrima, Andrea, Jonjic, Stipan, Schmitz, Ingo, Cicin-Sain, Luka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509765/
https://ncbi.nlm.nih.gov/pubmed/28770171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2017.00312
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