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Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes

The genomes of malaria parasites contain many genes of unknown function. To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei knockout mutants, representing >50% of the genome,...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell
Päätekijät: Bushell, Ellen, Gomes, Ana Rita, Sanderson, Theo, Anar, Burcu, Girling, Gareth, Herd, Colin, Metcalf, Tom, Modrzynska, Katarzyna, Schwach, Frank, Martin, Rowena E., Mather, Michael W., McFadden, Geoffrey I., Parts, Leopold, Rutledge, Gavin G., Vaidya, Akhil B., Wengelnik, Kai, Rayner, Julian C., Billker, Oliver
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509546/
https://ncbi.nlm.nih.gov/pubmed/28708996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.06.030
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