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Novel bio-spectroscopic imaging reveals disturbed protein homeostasis and thiol redox with protein aggregation prior to hippocampal CA1 pyramidal neuron death induced by global brain ischemia in the rat

Global brain ischemia resulting from cardiac arrest and cardiac surgery can lead to permanent brain damage and mental impairment. A clinical hallmark of global brain ischemia is delayed neurodegeneration, particularly within the CA1 subsector of the hippocampus. Unfortunately, the biochemical mechan...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Hackett, Mark J., Smith, Shari. E, Caine, Sally, Nichol, Helen, George, Graham N., Pickering, Ingrid J., Paterson, Phyllis G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509437/
https://ncbi.nlm.nih.gov/pubmed/26454085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.08.029
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