Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

Tissue-resident memory T (T(RM)) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens(1–4). However, the biological pathways that enable the long-term survival of T(RM) cells are obscure(4,5). Here we show that mouse CD8(+) T(RM) cells generated by viral in...

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Pubblicato in:Nature
Autori principali: Pan, Youdong, Tian, Tian, Park, Chang Ook, Lofftus, Serena Y., Mei, Shenglin, Liu, Xing, Luo, Chi, O’Malley, John T., Gehad, Ahmed, Teague, Jessica E., Divito, Sherrie J., Fuhlbrigge, Robert, Puigserver, Pere, Krueger, James G., Hotamisligil, Gökhan S., Clark, Rachael A., Kupper, Thomas S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509051/
https://ncbi.nlm.nih.gov/pubmed/28219080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21379
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