Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

Currently, major concerns about the safety and efficacy of RNA interference (RNAi)-based bone anabolic strategies still exist because of the lack of direct osteoblast-specific delivery systems for osteogenic siRNAs. Here we screened the aptamer CH6 by cell-SELEX, specifically targeting both rat and...

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Publicado no:Nat Med
Main Authors: Liang, Chao, Guo, Baosheng, Wu, Heng, Shao, Ningsheng, Li, Defang, Liu, Jin, Dang, Lei, Wang, Cheng, Li, Hui, Li, Shaohua, Lau, Wing Ki, Cao, Yu, Yang, Zhijun, Lu, Cheng, He, Xiaojuan, Au, DWT, Pan, Xiaohua, Zhang, Bao-Ting, Lu, Changwei, Zhang, Hongqi, Yue, Kinman, Qian, Airong, Shang, Peng, Xu, Jiake, Xiao, Lianbo, Bian, Zhaoxiang, Tan, Weihong, Liang, Zicai, He, Fuchu, Zhang, Lingqiang, Lu, Aiping, Zhang, Ge
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508976/
https://ncbi.nlm.nih.gov/pubmed/25665179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3791
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