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Janus kinase inhibitors prevent migration of rheumatoid arthritis neutrophils towards interleukin‐8, but do not inhibit priming of the respiratory burst or reactive oxygen species production
Neutrophils play a crucial role in the pathophysiology of rheumatoid arthritis (RA) via the release of reactive oxygen species (ROS), proteases and cytokines. Orally active Janus kinase (JAK) inhibitors (JAKi), e.g. baricitinib and tofacitinib, have high clinical efficacy in RA but are linked with n...
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| Publicado no: | Clin Exp Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508336/ https://ncbi.nlm.nih.gov/pubmed/28369741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12970 |
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