C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways

Biased agonism, the ability of different ligands for the same receptor to selectively activate some signaling pathways while blocking others, is now an established paradigm for G protein-coupled receptor signaling. One group of receptors in which endogenous bias is critical is the chemokine system,...

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Vydáno v:Mol Pharmacol
Hlavní autoři: Smith, Jeffrey S., Alagesan, Priya, Desai, Nimit K., Pack, Thomas F., Wu, Jiao-Hui, Inoue, Asuka, Freedman, Neil J., Rajagopal, Sudarshan
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508197/
https://ncbi.nlm.nih.gov/pubmed/28559424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.108522
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