Improved high sensitivity screen for Huntington disease using a one-step triplet-primed PCR and melting curve assay

Molecular diagnosis of Huntington disease (HD) is currently performed by fluorescent repeat-flanking or triplet-primed PCR (TP-PCR) with capillary electrophoresis (CE). However, CE requires multiple post-PCR steps and may result in high cost in high-throughput settings. We previously described a cos...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Zhao, Mingjue, Cheah, Felicia S. H., Chen, Min, Lee, Caroline G., Law, Hai-Yang, Chong, Samuel S.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507316/
https://ncbi.nlm.nih.gov/pubmed/28700716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180984
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