A Phase 2, Double-Blind, Placebo-Controlled Randomized Trial Assessing the Efficacy of ABT-436, a Novel V1b Receptor Antagonist, for Alcohol Dependence

Alcohol use disorder has been linked to dysregulation of the brain stress systems, producing a negative emotional state leading to chronic relapsing behavior. Vasopressin receptors appear to have a regulatory role in stress, anxiety, and alcohol. This study evaluated the novel compound, ABT-436, a V...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Ryan, Megan L, Falk, Daniel E, Fertig, Joanne B, Rendenbach-Mueller, Beatrice, Katz, David A, Tracy, Katherine A, Strain, Eric C, Dunn, Kelly E, Kampman, Kyle, Mahoney, Elizabeth, Ciraulo, Domenic A, Sickles-Colaneri, Laurie, Ait-Daoud, Nassima, Johnson, Bankole A, Ransom, Janet, Scott, Charles, Koob, George F, Litten, Raye Z
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506792/
https://ncbi.nlm.nih.gov/pubmed/27658483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.214
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