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Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity
We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide l...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5506438/ https://ncbi.nlm.nih.gov/pubmed/28401650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12595 |
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