Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking endogenous TPCs. In view of the control exert...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Pafumi, Irene, Festa, Margherita, Papacci, Francesca, Lagostena, Laura, Giunta, Cristina, Gutla, Vijay, Cornara, Laura, Favia, Annarita, Palombi, Fioretta, Gambale, Franco, Filippini, Antonio, Carpaneto, Armando
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505983/
https://ncbi.nlm.nih.gov/pubmed/28698624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04974-1
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