H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos

Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable production of cloned animals. Nuclear reprogramming is relatively inefficient, and the development of the resultant embryos is frequently compromised, in part due to the inappropriate expression of genes previously activ...

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發表在:Cell Stem Cell
Main Authors: Hörmanseder, Eva, Simeone, Angela, Allen, George E., Bradshaw, Charles R., Figlmüller, Magdalena, Gurdon, John, Jullien, Jerome
格式: Artigo
語言:Inglês
出版: Cell Press 2017
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Short Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505866/
https://ncbi.nlm.nih.gov/pubmed/28366589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.03.003
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