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Mitosis can drive cell cannibalism through entosis

Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphol...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Durgan, Joanne, Tseng, Yun-Yu, Hamann, Jens C, Domart, Marie-Charlotte, Collinson, Lucy, Hall, Alan, Overholtzer, Michael, Florey, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505699/
https://ncbi.nlm.nih.gov/pubmed/28693721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27134
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