NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells

Accumulating evidence has defined nucleophosmin 1 (NPM1) mutation as a driver genetic event in acute myeloid leukemia (AML), whereas the pathogenesis of NPM1-mutated AML remains to be fully elucidated. In this study, we showed that mutant NPM1 elevated autophagic activity and autophagic activation c...

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Enregistré dans:
Détails bibliographiques
Publié dans:Theranostics
Auteurs principaux: Zou, Qin, Tan, Shi, Yang, Zailin, Zhan, Qian, Jin, Hongjun, Xian, Jingrong, Zhang, Shuaishuai, Yang, Liyuan, Wang, Lu, Zhang, Ling
Format: Artigo
Langue:Inglês
Publié: Ivyspring International Publisher 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505061/
https://ncbi.nlm.nih.gov/pubmed/28740552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.19439
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