IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype

Mesenchymal stem cell- (MSC-) based therapy is a promising treatment for cartilage. However, repair tissue in general fails to regenerate an original hyaline-like tissue. In this study, we focused on increasing the expression levels for insulin-like growth factor-1 (IGF-1) to improve repair tissue q...

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Bibliographic Details
Published in:Stem Cells Int
Main Authors: Ikeda, Yasutoshi, Sakaue, Morito, Chijimatsu, Ryota, Hart, David A., Otsubo, Hidenori, Shimomura, Kazunori, Madry, Henning, Suzuki, Tomoyuki, Yoshikawa, Hideki, Yamashita, Toshihiko, Nakamura, Norimasa
Format: Artigo
Language:Inglês
Published: Hindawi 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504993/
https://ncbi.nlm.nih.gov/pubmed/28740513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5804147
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