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Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation

Animal studies have shown that autophagy is essential in the process of obesity. Here, we performed daily injection of the autophagy inhibitor chloroquine (CQ) in mice and found that systemic administration of CQ blocks high-fat diet-induced obesity. To investigate the potential underlying molecular...

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Pubblicato in:Am J Physiol Endocrinol Metab
Autori principali: Zhang, Chongben, He, Yingke, Okutsu, Mitsuhara, Ong, Lai Chun, Jin, Yi, Zheng, Lin, Chow, Pierce, Yu, Sidney, Zhang, Mei, Yan, Zhen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504416/
https://ncbi.nlm.nih.gov/pubmed/23800883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00640.2012
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