Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat

The treatment of heart failure (HF) is challenging and morbidity and mortality are high. The goal of this study was to determine if inhibition of the late Na(+) current with ranolazine during early hypertensive heart disease might slow or stop disease progression. Spontaneously hypertensive rats (ag...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Am J Physiol Heart Circ Physiol
Egile Nagusiak: Aistrup, Gary L., Gupta, Deepak K., Kelly, James E., O'Toole, Matthew J., Nahhas, Amanda, Chirayil, Nimi, Misener, Sol, Beussink, Lauren, Singh, Neha, Ng, Jason, Reddy, Mahendra, Mongkolrattanothai, Thitipong, El-Bizri, Nesrine, Rajamani, Sridharan, Shryock, John C., Belardinelli, Luiz, Shah, Sanjiv J., Wasserstrom, J. Andrew
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Physiological Society 2013
Gaiak:
Cardiac Excitation and Contraction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504390/
https://ncbi.nlm.nih.gov/pubmed/23873796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00401.2013
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