Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1, which is essential for viral genome maintenance but highly antigenic. EBV has seemingly evolved a system in which the mRNA sequence encoding the glycine-alanine repeats (GA...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Lista, María José, Martins, Rodrigo Prado, Billant, Olivier, Contesse, Marie-Astrid, Findakly, Sarah, Pochard, Pierre, Daskalogianni, Chrysoula, Beauvineau, Claire, Guetta, Corinne, Jamin, Christophe, Teulade-Fichou, Marie-Paule, Fåhraeus, Robin, Voisset, Cécile, Blondel, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504353/
https://ncbi.nlm.nih.gov/pubmed/28685753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16043
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