The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide, ribosome disassembly and recycling. Although ribosomal subunit dissociation and nascent peptide degradation are well-understood, the...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Garzia, Aitor, Jafarnejad, Seyed Mehdi, Meyer, Cindy, Chapat, Clément, Gogakos, Tasos, Morozov, Pavel, Amiri, Mehdi, Shapiro, Maayan, Molina, Henrik, Tuschl, Thomas, Sonenberg, Nahum
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504347/
https://ncbi.nlm.nih.gov/pubmed/28685749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16056
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