Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis

The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (...

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Udgivet i:Sci Rep
Main Authors: Ma, Ruishuang, Xie, Rui, Yu, Chengyuan, Si, Yu, Wu, Xiaoming, Zhao, Lu, Yao, Zhipeng, Fang, Shaohong, Chen, He, Novakovic, Valerie, Gao, Chunyan, Kou, Junjie, Bi, Yayan, Thatte, Hemant S., Yu, Bo, Yang, Shufen, Zhou, Jin, Shi, Jialan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504060/
https://ncbi.nlm.nih.gov/pubmed/28694452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04773-8
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