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Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells
Selective inhibitors of nuclear export (SINE) are small molecules in development as anti-cancer agents. The first-in-class SINE, selinexor, is in clinical trials for blood and solid cancers. Selinexor forms a covalent bond with exportin-1 at cysteine-528, and blocks its ability to export cargos. Pre...
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| Publicado no: | Oncotarget |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5503625/ https://ncbi.nlm.nih.gov/pubmed/28467801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17063 |
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