Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma

Dishevelled-3 (Dvl3) is regarded as a binding hub with many different interacting partners. However, its regulation and mechanism on cancer stemness remain to be explored. In this study, we showed that Dvl3 was significantly overexpressed in human hepatocellular carcinomas (HCCs) and promoted cancer...

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Publicado en:Oncotarget
Autores principales: Tsui, Yu-Man, Sze, Karen Man-Fong, Tung, Edmund Kwok-Kwan, Ho, Daniel Wai-Hung, Lee, Terence Kin-Wah, Ng, Irene Oi-Lin
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503623/
https://ncbi.nlm.nih.gov/pubmed/28455968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17049
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