Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells

Understanding cancer stem cell (CSC) maintenance pathways is critical for the development of CSC-targeting therapy. Here, we investigated the functional role of the cyclin D1-dependent activation of Smad2/3 and Smad4 in hepatocellular carcinoma (HCC) CSCs and in HCC primary tumors. Cyclin D1 sphere-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xia, Wei, Lo, Chung Mau, Poon, Randy Y.C., Cheung, Tan To, Chan, Albert C.Y., Chen, Lin, Yang, Sitian, Tsao, George S.W., Wang, Xiao Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503574/
https://ncbi.nlm.nih.gov/pubmed/28415588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16402
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