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Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene
In gene therapy, effective and selective suicide gene expression is crucial. We exploited the endogenous Long INterspersed Element-1 (L1) machinery often reactivated in human cancers to integrate the Herpes Simplex Virus Thymidine Kinase (HSV-TK) suicide gene selectively into the genome of cancer ce...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5503529/ https://ncbi.nlm.nih.gov/pubmed/28415677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16013 |
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