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Label-Free Measurements of Tenofovir Diffusion Coefficients in a Microbicide Gel using Raman Spectroscopy
Confocal Raman spectroscopy was implemented in a new label-free technique to quantify molecular diffusion coefficients within gels. A leading anti-HIV drug, tenofovir, was analyzed in a clinical microbicide gel. The gel was tested undiluted, and in 10 – 50%w/w dilutions with vaginal fluid simulant t...
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| Published in: | J Pharm Sci |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5503201/ https://ncbi.nlm.nih.gov/pubmed/27837968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.09.030 |
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