In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/β-catenin signaling pathway in osteosarcoma

BACKGROUND: The aim of the study was to explore the effects of microRNA-107 (miR-107) by targeting Dkk-1 on osteosarcoma (OS) via the Wnt/β-catenin signaling pathway. METHODS: OS and adjacent tissues were collected from 67 patients diagnosed with OS. Expressions of miR-107, Dkk-1, LRP5, β-catenin, a...

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Veröffentlicht in:Medicine (Baltimore)
Hauptverfasser: Zhang, Zhi-Cai, Liu, Jian-Xiang, Shao, Zeng-Wu, Pu, Fei-Fei, Wang, Bai-Chuan, Wu, Qiang, Zhang, Yu-Kun, Zeng, Xian-Lin, Guo, Xiao-Dong, Yang, Shu-Hua, He, Tong-Chuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer Health 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502147/
https://ncbi.nlm.nih.gov/pubmed/28682874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0000000000007245
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