Insufficient antibody validation challenges oestrogen receptor beta research

The discovery of oestrogen receptor β (ERβ/ESR2) was a landmark discovery. Its reported expression and homology with breast cancer pharmacological target ERα (ESR1) raised hopes for improved endocrine therapies. After 20 years of intense research, this has not materialized. We here perform a rigorou...

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Publicat a:Nat Commun
Autors principals: Andersson, Sandra, Sundberg, Mårten, Pristovsek, Nusa, Ibrahim, Ahmed, Jonsson, Philip, Katona, Borbala, Clausson, Carl-Magnus, Zieba, Agata, Ramström, Margareta, Söderberg, Ola, Williams, Cecilia, Asplund, Anna
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501969/
https://ncbi.nlm.nih.gov/pubmed/28643774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15840
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