Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B

BACKGROUND: Although alcohol risk is heritable, few genetic risk variants have been identified. Longitudinal (EHR) data offer a largely untapped source of phenotypic information for genetic studies, but EHR-derived phenotypes for harmful alcohol exposure have yet to be validated. Using a variant of...

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Gepubliceerd in:Alcohol Clin Exp Res
Hoofdauteurs: Justice, Amy C., McGinnis, Kathleen A., Tate, Jan, Xu, Ke, Becker, William C., Zhao, Hongyu, Gelernter, Joel, Kranzler, Henry R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501250/
https://ncbi.nlm.nih.gov/pubmed/28295416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13373
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