Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

BACKGROUND: Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Med
Main Authors: López Rodríguez, Maykel, Kaminska, Dorota, Lappalainen, Kati, Pihlajamäki, Jussi, Kaikkonen, Minna U., Laakso, Markku
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501007/
https://ncbi.nlm.nih.gov/pubmed/28683826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0453-x
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