Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells

Platinum-resistance is a major limitation to effective chemotherapy regimens in high-grade serous ovarian cancer (HGSOC). To better understand the mechanisms involved we characterized the proteome and phosphoproteome in cisplatin sensitive and resistant HGSOC primary cells using a mass spectrometry-...

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Bibliographic Details
Published in:Mol Cell Proteomics
Main Authors: Nguyen, Elizabeth V., Huhtinen, Kaisa, Goo, Young Ah, Kaipio, Katja, Andersson, Noora, Rantanen, Ville, Hynninen, Johanna, Lahesmaa, Riitta, Carpen, Olli, Goodlett, David R.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2017
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500768/
https://ncbi.nlm.nih.gov/pubmed/28455291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.058321
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