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Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death

TNFα is a potent inducer of inflammation due to its ability to promote gene expression, in part via the NFκB pathway. Moreover, in some contexts, TNFα promotes Caspase-dependent apoptosis or RIPK1/RIPK3/MLKL-dependent necrosis. Engagement of the TNF Receptor Signaling Complex (TNF-RSC), which contai...

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書目詳細資料
發表在:Mol Cell Proteomics
Main Authors: Mohideen, Firaz, Paulo, Joao A., Ordureau, Alban, Gygi, Steve P., Harper, J. Wade
格式: Artigo
語言:Inglês
出版: The American Society for Biochemistry and Molecular Biology 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500755/
https://ncbi.nlm.nih.gov/pubmed/28539327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M117.068189
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