Fungus-derived hydroxyl radicals kill hepatic cells by enhancing nuclear transglutaminase

We previously reported the importance of induced nuclear transglutaminase (TG) 2 activity, which results in hepatic cell death, in ethanol-induced liver injury. Here, we show that co-incubation of either human hepatic cells or mouse primary hepatocytes derived from wild-type but not TG2(−/−) mice wi...

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Publicado en:Sci Rep
Main Authors: Shrestha, Ronak, Shrestha, Rajan, Qin, Xian-Yang, Kuo, Ting-Fang, Oshima, Yugo, Iwatani, Shun, Teraoka, Ryutaro, Fujii, Keisuke, Hara, Mitsuko, Li, Mengqian, Takahashi-Nakaguchi, Azusa, Chibana, Hiroji, Lu, Jun, Cai, Muyi, Kajiwara, Susumu, Kojima, Soichi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500562/
https://ncbi.nlm.nih.gov/pubmed/28684792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04630-8
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