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Depletion of topoisomerase IIα leads to a shortening in metaphase interkinetochore distance and the abnormal persistence of PICH-coated anaphase threads
Topoisomerase II is a major component of mitotic chromosomes and its unique decatenating activity has been implicated in many aspects of chromosome dynamics, of which chromosome segregation is the most seriously affected by loss of topo II activity in living cells. There is considerable evidence tha...
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| Publicado en: | J Cell Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5500177/ https://ncbi.nlm.nih.gov/pubmed/17956945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.013730 |
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