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Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance

Targeted approaches to treat autoimmune diseases would improve upon current therapies that broadly suppress the immune system and lead to detrimental side effects. Antigen-specific tolerance was induced using poly(lactide-co-glycolide) nanoparticles conjugated with disease-relevant antigen to treat...

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Опубликовано в: :Mol Ther
Главные авторы: Kuo, Robert, Saito, Eiji, Miller, Stephen D., Shea, Lonnie D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498812/
https://ncbi.nlm.nih.gov/pubmed/28408181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.03.032
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