Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 T cells are infrequently found within germinal centers (GCs), a predominant site of active and latent HIV infec...

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Publicado no:Sci Transl Med
Principais autores: Petrovas, Constantinos, Ferrando-Martinez, Sara, Gerner, Michael Y., Casazza, Joseph P., Pegu, Amarendra, Deleage, Claire, Cooper, Arik, Hataye, Jason, Andrews, Sarah, Ambrozak, David, Del Río Estrada, Perla M., Boritz, Eli, Paris, Robert, Moysi, Eirini, Boswell, Kristin L., Ruiz-Mateos, Ezequiel, Vagios, Ilias, Leal, Manuel, Ablanedo-Terrazas, Yuria, Rivero, Amaranta, Gonzalez-Hernandez, Luz Alicia, McDermott, Adrian B., Moir, Susan, Reyes-Terán, Gustavo, Docobo, Fernando, Pantaleo, Giuseppe, Douek, Daniel C., Betts, Michael R., Estes, Jacob D., Germain, Ronald N., Mascola, John R., Koup, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497679/
https://ncbi.nlm.nih.gov/pubmed/28100833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag2285
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