Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I

Peroxiredoxin I (Prx I) plays an important role in cancer development and inflammation. It is a dual-functional protein which acts as both an antioxidant enzyme and a molecular chaperone. While there have been intensive studies on its peroxidase activity, Prx I's chaperone activity remains elus...

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Vydáno v:Chem Sci
Hlavní autoři: Zhao, Qian, Ding, Yu, Deng, Zhangshuang, Lee, On-Yi, Gao, Peng, Chen, Pin, Rose, Rebecca J., Zhao, Hong, Zhang, Zhehao, Tao, Xin-Pei, Heck, Albert J. R., Kao, Richard, Yang, Dan
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2015
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497274/
https://ncbi.nlm.nih.gov/pubmed/28717468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00633c
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