Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing

Mammalian target of rapamycin complex 1 (mTORC1) and cell senescence are intimately linked to each other and to organismal aging. Inhibition of mTORC1 is the best-known intervention to extend lifespan, and recent evidence suggests that clearance of senescent cells can also improve health and lifespa...

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Vydáno v:J Cell Biol
Hlavní autoři: Carroll, Bernadette, Nelson, Glyn, Rabanal-Ruiz, Yoana, Kucheryavenko, Olena, Dunhill-Turner, Natasha A., Chesterman, Charlotte C., Zahari, Qabil, Zhang, Tong, Conduit, Sarah E., Mitchell, Christina A., Maddocks, Oliver D.K., Lovat, Penny, von Zglinicki, Thomas, Korolchuk, Viktor I.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496614/
https://ncbi.nlm.nih.gov/pubmed/28566325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610113
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