TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1

Endothelial cell adhesion and migration are critical steps of the angiogenic process, whose dysfunction is associated with tumor growth and metastasis. The TRPM8 channel has recently been proposed to play a protective role in prostate cancer by impairing cell motility. However, the mechanisms by whi...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Genova, Tullio, Grolez, Guillaume P., Camillo, Chiara, Bernardini, Michela, Bokhobza, Alexandre, Richard, Elodie, Scianna, Marco, Lemonnier, Loic, Valdembri, Donatella, Munaron, Luca, Philips, Mark R., Mattot, Virginie, Serini, Guido, Prevarskaya, Natalia, Gkika, Dimitra, Pla, Alessandra Fiorio
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496606/
https://ncbi.nlm.nih.gov/pubmed/28550110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201506024
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