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Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export

The mRNA export adaptor Yra1p/REF contributes to nascent mRNP assembly and recruitment of the export receptor Mex67p. yra1 mutants exhibit mRNA export defects and a decrease in LacZ reporter and certain endogenous transcripts. The loss of Mlp1p/Mlp2p, two TPR-like proteins attached to nuclear pores,...

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Autors principals: Vinciguerra, Patrizia, Iglesias, Nahid, Camblong, Jurgi, Zenklusen, Daniel, Stutz, Françoise
Format: Artigo
Idioma:Inglês
Publicat: 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC549612/
https://ncbi.nlm.nih.gov/pubmed/15692572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600527
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