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Insulated transcriptional elements enable precise design of genetic circuits

Rational engineering of biological systems is often complicated by the complex but unwanted interactions between cellular components at multiple levels. Here we address this issue at the level of prokaryotic transcription by insulating minimal promoters and operators to prevent their interaction and...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Zong, Yeqing, Zhang, Haoqian M., Lyu, Cheng, Ji, Xiangyu, Hou, Junran, Guo, Xian, Ouyang, Qi, Lou, Chunbo
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495784/
https://ncbi.nlm.nih.gov/pubmed/28674389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00063-z
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