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Insulated transcriptional elements enable precise design of genetic circuits

Rational engineering of biological systems is often complicated by the complex but unwanted interactions between cellular components at multiple levels. Here we address this issue at the level of prokaryotic transcription by insulating minimal promoters and operators to prevent their interaction and...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Zong, Yeqing, Zhang, Haoqian M., Lyu, Cheng, Ji, Xiangyu, Hou, Junran, Guo, Xian, Ouyang, Qi, Lou, Chunbo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495784/
https://ncbi.nlm.nih.gov/pubmed/28674389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00063-z
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