MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

Rapid cellular proliferation in early development and cancer depends on glucose metabolism to fuel macromolecule biosynthesis. Metabolic enzymes are presumed regulators of this glycolysis-driven metabolic program, known as the Warburg effect; however, few have been identified. We uncover a previousl...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shtraizent, Nataly, DeRossi, Charles, Nayar, Shikha, Sachidanandam, Ravi, Katz, Liora S, Prince, Adam, Koh, Anna P, Vincek, Adam, Hadas, Yoav, Hoshida, Yujin, Scott, Donald K, Eliyahu, Efrat, Freeze, Hudson H, Sadler, Kirsten C, Chu, Jaime
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495572/
https://ncbi.nlm.nih.gov/pubmed/28644127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22477
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